We are thrilled to announce that our CEO Alexandre SANTINHO and our CSO Abdou-Rachid Thiam have recently published a groundbreaking paper in the prestigious journal, Nature Communications. The research paper, titled "Giant organelle vesicles to uncover intracellular membrane mechanics and plasticity," offers novel insights into the complex world of intracellular membranes.

This paper is the cornerstone of Oria Bioscience's cutting-edge technology. The insights gained from this research are integral to our innovative approaches in cellular biology and therapeutic development.

We invite you to delve deeper into this fascinating study by reading the full article :

‍Read the Full Article

The Study at a Glance

Intracellular membranes play a crucial role in maintaining cellular integrity and function. However, understanding their mechanics and plasticity has always been a challenging task for scientists. This study introduces a revolutionary method to generate Giant Organelle Vesicles (GOVs) by subjecting cells to a hypotonic medium followed by plasma membrane breakage. These GOVs, ranging from 3 to 10 micrometers in diameter, provide a unique platform to study the mechanical properties of intracellular membranes.

Key Findings

Generation of GOVs: The researchers successfully created GOVs by exposing cells to a hypotonic solution, which causes the cells to swell and eventually break the plasma membrane. This process results in the formation of large vesicles that encapsulate various organelles.

‍Mechanical Properties: By analyzing these GOVs, the study reveals critical information about the mechanical properties of intracellular membranes. The findings suggest that these membranes exhibit remarkable plasticity, allowing them to adapt to various physiological conditions.

‍Implications for Cell Biology: Understanding the mechanics of intracellular membranes opens new avenues for research in cell biology. It provides a deeper understanding of how cells maintain their structure and function under different conditions, which could have significant implications for disease research and drug development.

Why This Matters

The ability to study intracellular membranes in such detail is a significant advancement in the field of cell biology. This research not only enhances our understanding of cellular mechanics but also paves the way for future studies that could lead to new therapeutic strategies for various diseases.

Stay tuned for more updates and insights from our team as we continue to explore the fascinating world of cellular biology.

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