FROM CELLS TO ORGANELLES• ORGANELLES•

First-in-Class Isolated Organelles for Drug Discovery

OUR PRODUCTS

Spark the therapies of tomorrow by opening the frontiers of the unreachable

We bring best-in-class organelles to scientists, to accelerate life science discoveries.

With our patented microfluidic process, organelles are isolated through a controlled, gentle mechanical extraction and sorting workflow. For the first time, pure organelles are delivered at scale and designed for any therapeutic are.

At ORIA, we strongly believe that organelle-based solutions will drive tomorrow’s breakthroughs in Drug Discovery.

Our Technology

De-risk and accelerate your Drug Discovery

Our proprietary microfluidic platform isolates pure, functionally intact organelles at industrial scale. Preparations maintain >90% purity and multi-month stability, with batch-to-batch reproducibility conventional extraction cannot deliver. Shifting research from whole-cell models to native organelle systems unlocks unprecedented biological relevance. This organelle-centric approach reveals mechanisms inaccessible in cells and accelerates the path from screening to clinical nomination. Early-stage R&D timelines compress, Hit-to-Lead and lead optimization decisions gain more predictive power, and therapeutic opportunities emerge that competitors are still searching for.

Cost and time reduction

Faster Go/no-Go decisions

Reduced early-stage R&D risks

PRODUCTS •

LYSO-Prep™

Ready-to-use preparations of isolated functional lysosomes

Your tailored prep

MITO-Prep™

Ready-to-use preparations of isolated functional mitochondria

ORGANELLES -Preps™

Discover the ORGANELLES-Preps™ product range. Our wide selection of organellar preparations are designed from the specialized cell type of your choice and tailored to your therapeutic areas of work. They are also customizable to meet your highly specific needs. Our organelles keep their physiological integrity, are ready-to-use and available at scale.

SEE ALL PREPS

Highly Pure & Fully Functional

Available at Scale

Ready-to-Use

OUR TECHNOLOGY •

Organelles are isolated through a patented microfluidics workflow. This allows to extract and sort millions of organelles per hour while preserving their biophysical integrity.

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THERAPEUTIC AREAS •

From neurodegenerative disorders to immunology and metabolic diseases, our organelles are especially designed to suit your focus area.

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APPLICATION AREAS •

Our organelle-based solutions have been designed to be compatible with your workflows and applications.

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Trusted by customers who choose our ORGANELLES•

Pharmaceutical Companies

Supporting your next blockbuster drug and mechanism of action

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Contract Research Organizations

Delivering more reliable and reproducible data on time

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BioTech Companies

Pushing the boundaries of innovation ever further

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Academic Researchers

Ensuring your next scientific breakthroughs

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KEY PARTNERS •

LYSO-Prep™ for organellar electrophysiology: A new tool for high throughput measurement of lysosomal TRPML1 channels using the SyncroPatch 384, SURFE2R N1 and SURFE2R 96SE

with Nanion Technologies

The gold standard to functionally characterize lysosomal ion channels remains manual patch clamp recordings of enlarged individual lysosomes isolated from individual cells1. This technique is time-consuming and technically challenging, but other electrophysiological techniques are beginning to overcome these challenges, resulting in higher throughput characterization of isolated lysosomes. One of these techniques is automated patch clamp (APC), which uses a planar glass substrate for whole lysosome patch clamp recordings. When using lysosomes with APC, it is still necessary to isolate the lysosomes from the cell, which can be a lengthy process and requires precise timing in order to be used effectively with APC. Another technique to assess lysosomal ion channels is solid-supported membrane-based electrophysiology (SSME). This emergent method has been successfully used to record native lysosomes isolated using sequential centrifugation steps.

New frontier: Investigating regulation of lysosomal ion channels at elevated temperatures in the native system

with Nanion Technologies

Ion channel activity is modulated by various stimuli including voltage, pH, lipids or neurotransmitters that turn various inputs into electrical signals. In addition, the activity can also be modulated by temperature with the example of the transient receptor potential (TRP) family of ion channels that show a remarkably high sensitivity to changes in temperature and mediate temperature-sensation in animals.

Breaking barriers in lysosomal electrophysiology: Automated solutions for ion channel analysis

with Sophion Bioscience

Automated Patch Clamp (APC) of lysosomal ion channels was achieved using enlarged lysosomes (LYSO-Prep™, Oria Biosci ence), enabling measurement of ion channel activity such as TRPML1. Lysosomes were successfully captured on two Sophion systems, with success rates of 69.9 ± 3.2% on the QPatch® 48 and 74.6 ± 2.6% on the Qube® 384. The lysosomal recordings showed stable seals and robust TRPML1 current responses. Ag onist concentration–response curves produced EC50 values that were reproducible on both platforms and in good agreement with published data8. Based on these results, Sophion’s medi um- and high-throughput APC systems provide a reliable and scalable approach for studying lysosomal ion channel pharma cology, including TRPML1.